Zepbound
Tirzepatide · Eli Lilly
FDA Approved: November 8, 2023
Brand Price
$900-$1,200/month
Compounded
$299-$499/month
Insurance
Varies by plan (often requires PA)
Type
Weekly Injection
About Zepbound
Zepbound (tirzepatide) is FDA-approved for chronic weight management. It is the same medication as Mounjaro but approved specifically for weight loss. It is considered one of the most effective weight loss medications available.
Zepbound is a dual GLP-1/GIP receptor agonist, activating two hormone pathways to reduce appetite, slow digestion, and improve metabolic function. This dual action may lead to greater weight loss than GLP-1-only medications.
Effectiveness: In clinical trials, participants lost an average of 18-22% of body weight over 72 weeks when combined with diet and exercise. About 96% of participants lost at least 5% of body weight.
Dosage & Administration
Starting Dose
2.5 mg once weekly
Maintenance Dose
5-15 mg once weekly
Maximum Dose
15 mg once weekly
Frequency
Weekly injection
Side Effects
Common Side Effects (Common (≥10%))
- •Nausea (33%)
- •Diarrhea (24%)
- •Vomiting (20%)
- •Constipation (18%)
- •Abdominal pain (14%)
- •Injection site reactions (10%)
Serious Side Effects
Seek immediate medical attention if you experience any of these:
- Pancreatitis
- Gallbladder problems
- Severe gastrointestinal disease
- Severe allergic reactions
Who Should Not Take Zepbound
- Personal or family history of medullary thyroid carcinoma (MTC)
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Severe gastrointestinal disease
- Pregnancy
Current Shortage Status
Severe Shortage
Extremely high demand, manufacturing capacity limits
Alternatives: Consider compounded tirzepatide or other GLP-1 medications. Use our Alternatives Hub to compare options.
Pricing & Cost
Brand Name Price
$900-$1,200/month
Without insurance or savings card. Actual price varies by pharmacy and location.
Compounded Alternative
$299-$499/month
Compounded tirzepatide from licensed pharmacies. Often HSA/FSA eligible.
With Insurance
$0-$350/month
Cost depends on your plan. Prior authorization may be required.
Insurance Coverage
Drug Interactions
Important: Tell your doctor about all medications you are taking, including prescription, over-the-counter, and herbal supplements.
- Insulin: May increase risk of hypoglycemia. Monitor blood sugar closely.
- Sulfonylureas: May increase risk of hypoglycemia. Dose reduction may be needed.
- Warfarin: Monitor INR more frequently.
- Oral contraceptives: May reduce effectiveness. Use additional contraception.
Important Warnings
- Do not use if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
- Stop taking Zepbound and seek immediate medical attention if you experience severe abdominal pain.
- Inform your doctor if you have a history of pancreatitis, gallbladder disease, or kidney problems.
- Pregnant women should not use Zepbound. Use effective contraception while taking this medication.
Storage & Administration
Storage Instructions
Store Zepbound pens in the refrigerator (36°F to 46°F) before first use. After first use, store at room temperature (up to 86°F) or in the refrigerator. Do not freeze. Discard after 56 days.
How to Administer
Inject Zepbound subcutaneously (under the skin) in your stomach, thigh, or upper arm. Rotate injection sites. Use a new needle for each injection.
What to Monitor
Monitor for signs of pancreatitis (severe abdominal pain), gallbladder problems (pain in upper right abdomen), kidney problems (decreased urination), and allergic reactions. Regular check-ups with your doctor are recommended.
Alternatives to Zepbound
If Zepbound is not available, too expensive, or not covered by your insurance, consider these alternatives: