Mounjaro
Tirzepatide · Eli Lilly
FDA Approved: May 13, 2022
Brand Price
$900-$1,200/month
Compounded
$299-$499/month
Insurance
Usually covered for Type 2 diabetes
Type
Weekly Injection
About Mounjaro
Mounjaro (tirzepatide) is FDA-approved for Type 2 diabetes and is considered one of the most effective GLP-1 medications. It targets both GLP-1 and GIP receptors, potentially leading to greater weight loss than semaglutide.
Mounjaro is a dual GLP-1/GIP receptor agonist, meaning it activates two hormone pathways simultaneously. This dual action may lead to greater weight loss and blood sugar control than GLP-1-only medications.
Effectiveness: For diabetes: Reduces A1C by 2.0-2.5%. For weight loss (off-label): Users typically lose 15-22% of body weight over 6-12 months, potentially more than semaglutide.
Dosage & Administration
Starting Dose
2.5 mg once weekly
Maintenance Dose
5-15 mg once weekly
Maximum Dose
15 mg once weekly
Frequency
Weekly injection
Side Effects
Common Side Effects (Common (≥5%))
- •Nausea (17%)
- •Diarrhea (13%)
- •Vomiting (10%)
- •Constipation (10%)
- •Abdominal pain (7%)
- •Decreased appetite (6%)
Serious Side Effects
Seek immediate medical attention if you experience any of these:
- Pancreatitis
- Gallbladder problems
- Severe gastrointestinal disease
- Severe allergic reactions
- Diabetic retinopathy complications
Who Should Not Take Mounjaro
- Personal or family history of medullary thyroid carcinoma (MTC)
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Severe gastrointestinal disease
- Type 1 diabetes
Current Shortage Status
Limited Supply
High demand exceeding supply, manufacturing constraints
Alternatives: Consider compounded tirzepatide or other GLP-1 medications. Use our Alternatives Hub to compare options.
Pricing & Cost
Brand Name Price
$900-$1,200/month
Without insurance or savings card. Actual price varies by pharmacy and location.
Compounded Alternative
$299-$499/month
Compounded tirzepatide from licensed pharmacies. Often HSA/FSA eligible.
With Insurance
$0-$350/month
Cost depends on your plan. Prior authorization may be required.
Insurance Coverage
Drug Interactions
Important: Tell your doctor about all medications you are taking, including prescription, over-the-counter, and herbal supplements.
- Insulin: May increase risk of hypoglycemia. Monitor blood sugar closely.
- Sulfonylureas: May increase risk of hypoglycemia. Dose reduction may be needed.
- Warfarin: Monitor INR more frequently.
- Oral contraceptives: May reduce effectiveness. Use additional contraception.
Important Warnings
- Do not use if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
- Stop taking Mounjaro and seek immediate medical attention if you experience severe abdominal pain.
- Inform your doctor if you have a history of pancreatitis, gallbladder disease, or kidney problems.
- Pregnant women should not use Mounjaro. Use effective contraception while taking this medication.
Storage & Administration
Storage Instructions
Store Mounjaro pens in the refrigerator (36°F to 46°F) before first use. After first use, store at room temperature (up to 86°F) or in the refrigerator. Do not freeze. Discard after 56 days.
How to Administer
Inject Mounjaro subcutaneously (under the skin) in your stomach, thigh, or upper arm. Rotate injection sites. Use a new needle for each injection.
What to Monitor
Monitor blood sugar levels regularly, especially if taking insulin or other diabetes medications. Watch for signs of pancreatitis, gallbladder problems, and allergic reactions.
Alternatives to Mounjaro
If Mounjaro is not available, too expensive, or not covered by your insurance, consider these alternatives: